Contained Dust Collector for Potent Compound Handling in Tablet Presses - LEFILTER Solution

Product Introduction:

LEFILTER's containment dust collectors are engineered to the highest standards of cGMP and industrial hygiene for the pharmaceutical industry. Constructed entirely from 316L or 304 stainless steel with polished internal welds (Ra < 0.8 µm), these units are designed for cleanability and product integrity. The heart of the system is the Safe-Change HEPA Filter Housing, which allows for the removal and disposal of the primary HEPA filter cartridge without operator exposure to the potent compound. We utilize PTFE membrane-based HEPA cartridges offering 99.99% efficiency on particles down to 0.3 microns. The system operates under constant negative pressure and is often integrated with Nitrogen Inerting ports for processing solvent-wet or pyrophoric materials. All controls are designed to support validation protocols, with data logging for key parameters.

Application Area:

This system is essential for containment at tablet compression and capsule filling machines handling Active Pharmaceutical Ingredients (APIs) classified under OEB (Occupational Exposure Band) 4 or 5. During the high-speed compression of powder blends, fine dust is generated at the feed frame, punch guides, and tablet discharge chute. This dust contains highly potent compounds where even minimal operator exposure poses a significant health risk and requires stringent control. The challenge is to capture this dust with absolute reliability while providing a sealed, cleanable system that prevents cross-contamination between product batches and facilitates safe maintenance.

Our Solution:

LEFILTER offers more than a filter; we provide a complete containment strategy. Our systems are directly connected to the containment interfaces of the tablet press (e.g., isolator gloves or split valves). The air flow is meticulously calculated to ensure effective capture at all generation points while maintaining the required negative pressure within the process equipment. The design facilitates CIP (Clean-In-Place) and SIP (Steam-In-Place) capabilities. We provide full validation support documentation (DQ, IQ, OQ protocols) to streamline your regulatory compliance. By effectively capturing potent dust at the source, our solution protects operator safety, ensures product purity, minimizes costly API loss, and provides audit-ready compliance with FDA, EMA, and other global regulatory body requirements.

Call to Action:

Upgrading your potent compound handling to meet modern containment standards? Partner with LEFILTER. Our expertise in pharmaceutical dust control ensures a validated, reliable solution that safeguards your people and your products.